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KMID : 1039920160230010016
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Neonatal Medicine
2016 Volume.23 No. 1 p.16 ~ p.22
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Clinical Significance of Newborn Gastric Inflammatory Mediators
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Kim Young-Don
Shim Soon-Sup
Kang Hye-Sim
Maeng Young-Hee
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Abstract
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Purpose: We performed this study to determine (1) whether the levels of inflammatory mediators, including matrix metalloproteinase9 (MMP9) and intercellular adhesion molecule3 (ICAM3), in gastric fluid (GF) in premature newborns are associated with those in amniotic fluid (AF) in their mothers and (2) whether the levels of the inflammatory mediators in newborn GF are associated with the presence of intrauterine inflammation (IUI).
Methods: Sixtytwo pairs of pregnant women and their premature newborns born at <35 weeks’ gestation by cesarean delivery were enrolled in this study. AF and newborn GFs were obtained during cesarean section procedures. Levels of MMP9, ICAM3, interleukin6 (IL6), interleukin8 (IL8), and tumor necrosis factorα (TNFα) were measured and compared between the AF and newborn GFs in each dyad, according to the presence or absence of chorioamnionitis (CA), preterm prelabor rupture of membranes (PPROM), and preterm labor (PTL).
Results: The levels of MMP9, ICAM3, IL6, IL8, and TNFα in newborn GF were significantly correlated with those in AF in each dyad. The premature newborns and their mothers with CA had significantly higher GF MMP9, IL8, and TNFα levels than those without CA. Those with PPROM or PTL showed similar findings in terms of GF MMP9, IL8, and TNFα levels.
Conclusion: The newborn GF immediately after birth can be a useful alternative source of information on whether a premature infant has been exposed to IUI at the time of delivery.
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KEYWORD
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Inflammation, Chorioamnionitis, Premature infants, Gastric fluid, Matrix metalloproteinase, Intercellular adhesion molecule
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